HEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF PARTIAL AND COMPLETE SPLENECTOMY IN DOGS

Ibrahim I Elshahawy ,Korittum A.s ,Mohamed A Lebda

doi:10.21608/avmj.2018.168904

Abstract

The purpose of the current study was to describe the effect of surgical splenectomy technique either partial or complete on some biochemical and hematological parameters. Six male mature mongrel dogs were subdivided into two groups (complete and partial splenectomy), and six immature mongrel dogs were subdivided into two groups (complete and partial splenectomy). Blood samples were taken before (base line), 10, 30, and 60 days post-operative. The results showed a significant reduction in serum albumin and iron levels 10 days after partial and complete splenectomy in both immature and mature dogs. However, serum gamma globulin fraction, ferritin, transferrin, and ceruloplasmin concentrations were significantly increased at the same period following surgical operation. There was a perturbation in serum activity of transaminases, bilirubin, and urea levels. The levels of WBCs, neutrophils, lymphocytes, MCH, MCHC, and platelets in completely splenectomized immature and mature dogs were increased. While, the RBCs and Hb concentrations were significantly decreased following complete splenectomy in immature and mature dogs. These results concluded that splenectomy in dogs may induce anemia, thrombosis, and inflammatory conditions but also increase cellular and humeral immunity as a compensatory mechanism. Key words: Splenectomy, transferrin, platelets, ceruloplasmin, dogs

Highlights

The spleen, one of the most vascularized organs of the body and consider as a part of the mononuclear phagocyte system which is located between the portal and systemic circulations
The reduction of serum albumin post operation was as part of the systemic response to surgical trauma which was agreed with previous studies
Concerning iron balance, serum iron concentration was decreased with significant increase in serum ferritin, transferring, and ceruloplasmin in dogs under both types of splenectomy

Summary

Introduction

The spleen, one of the most vascularized organs of the body and consider as a part of the mononuclear phagocyte system which is located between the portal and systemic circulations. The spleen plays important functions, including hematopoiesis, cell purification and reservoir of blood elements (Sipka et al, 2006). The indications for total splenectomy include tumors, benign splenic lesions, splenic torsion, traumatism and hematological immune-mediated diseases not responsive to treatments with drugs (Harari, 1999). Partial splenectomy is indicated in animals with traumatic or focal lesions of the spleen to preserve splenic function. Complete removal of the spleen may lead to undesirable effect such as post-operative infections and sepsis, due to the reduce production of antibodies and phagocytes or may lead to thrombosis, due to rose of platelet count in blood (Khan et al, 2009)

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