HEMATOLOGICAL AND BIOCHEMICAL ALTERATIONS INDUCED BY TRAMADOL ADMINISTRATION IN MALE ALBINO RATS

Aziza A.m El-Shafey ,Doaa S Ibrahim ,Moshira M.e Seliem ,Haitham A.s Ibrahim

doi:10.21608/avmj.2019.168723

Abstract

The use of analgesics to alleviate the severe pains associated with many diseases is necessary. It is therefore important to study the effects of administration these analgesics to determine the side effects for their use. Hence we decided to study the hematological and biochemical effects of tramadol and tramadol withdrawal on male albino rats. Rats were divided into four control rat groups (7 rats each), and four tramadol rat groups (7 rats each); two groups administrated a daily oral dose of tramadol (20 mg/kg b.wt) for 30 and 60 days and two groups also administrated a daily oral dose of tramadol for 30 and 60 days then tramadol withdrawal for 7 days. Hemoglobin (Hb) content, red blood cells (RBCs) count, hematocrit (Hct) value, and lipid profile decreased, while white blood cells (WBCs) and platelets counts, liver function enzymes, and kidney function parameters increased after tramadol administration. Most parameters improved after tramadol withdrawal. The study showed the harmful effects of tramadol on the hematological and biochemical parameters and the effects of improvement on rats after tramadol withdrawal from them, especially after a short period.

Highlights

Analgesics are a group of drugs that act in different ways on the central nervous system to analgesia and relief from pain (Kumar et al, 2010)
This study aims to investigate the effects of administration a daily oral dose (20 mg/kg b.wt) of tramadol for 30 and 60 days on the hematological and biochemical parameters and the tramadol withdrawal effects
The count of red blood cells (RBCs) in all tramadol groups except in the group that administrated tramadol for 30 days decreased compared to their control groups

Summary

Introduction

Analgesics are a group of drugs that act in different ways on the central nervous system to analgesia and relief from pain (Kumar et al, 2010). In moderate and severe pain cases, opioid analgesic drugs are mainly used (El Shal and Selim, 2015). Opioid analgesic drugs might be obtained from natural sources (e.g. morphine, codeine) or from synthetic sources (as Tramadol, heroin, Hussein et al, 2017a). Continuous tramadol administration leads to the appearance of its toxic effects on various organs of the body (Shadnia et al, 2008). Tramadol has toxic effects on the structure and function of hepatic, renal and testicular tissues of male albino rats (Youssef and Zidan, 2016). High doses of tramadol cause neuronal degeneration in the rat brain (Atici et al, 2005) and alter brain neurotransmitter levels (Bloms-Funke et al, 2011)

Objectives

Methods

Results

Conclusion