Hemato-biochemical status of laboratory mice with a GM corn based diet

Abstract

GM analogues have about 30 plant species, and main share from GM crops belong to soybean and corn. According to the literature data, the introduction of GM fodder in the diet of laboratory mice and rats was accompanied by negative consequences for the health of experimental animals and their offspring. Corn is a component of animal feed and popular product among people, especially sweet canned corn. The lack of experimental data regarding effects of canned sweet GM corn on an organism was the drive behind our research subject. The objective of the research was a comparative analysis of hematological and biochemical parameters of laboratory mice with a conserved GM corn based diet and without it. Clinical blood analysis indicated the development of hyperchromic anemia, leukocytosis due to an increase in the fraction of medium blood cells and thrombocytosis in experimental group mice. Biochemical studies of these mice blood revealed signs of renal and liver pathology, myocardial damage and hyperproteinemia. A comparative analysis of the hemato-biochemical status of laboratory mice indicated the development of signs of anemia, intoxication and allergy in the group of mice with a conserved GM corn based diet as compared to intact mice of the control groups.