Hemato-Biochemical Alterations in Water Buffaloes Clinically Infected with Bovine Theileriosis before and after tTreatment by Buparvaquone

Abstract

Many studies have been done about theileriosis in cows and derelict its effect in water buffaloes. So this study was carried out to ascertain the changes in hematology and serum constituents in buffaloes affected with bovine theileriosis in Egypt. A total of 19 buffaloes of age 2-5 years were included in the study. Other animals of same age were kept as healthy controls. The affected animals showed signs and symptoms of bovine theileriosis included high fever, enlarged prescapular lymph nodes, corneal opacity, lacrimation, etc. Blood smears confirm the presence of T. annulata piroplasms in red blood cells. Hematological studies revealed decrease in erythrocytic count, packed cell volume and hemoglobin before treatment of theileria infected buffaloes, normocytic normochromic in theileria infected buffaloes and macrocytic hypochromic at one week post buparvaquone administration. Leucogram revealed leucocytosis. theileria infected buffaloes revealed increase in the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and serum levels of total bilirubin, unconjugated bilirubin (UB), conjugated bilirubin (CB), creatinine and blood urea nitrogen level. In contrary, total serum proteins and albumin showed significant decrease. Antioxidants results revealed a significant increase in Malondialdehyde (MDA) activity and a significant decease in the activity of catalase (CAT) in T. annulata clinically infected buffaloes. These alterations were improved by treatment the diseased animals by buparvaquone 2 weeks post administration.