Abstract
Hemangiosarcoma is a common neoplasm in dogs and less frequently seen in cats. In nonhuman primates, this tumor is rarely reported. A 17 year-old female spider monkey ( Ateles paniscus) was submitted an ultrasound exam due to gestation suspicion, which was seen a circular mass intra-uterine measuring 1.3 cm. New exams shown increase of the mass to 4.4 x 3.0 cm associated with a viable fetus. Was realized cesarean with ovariohysterectomy and excision of the mass; however the animal died in less than 24 hours after the surgery. In the necropsy, severe hemoabdomen was evidenced, although the surgical stumps were properly ligated and the complete sutures. Macroscopically, the uterine mass was soft, dark heterogeneous and measuring 5.0 cm in diameter. Histologically was visualized proliferation of spindle cells that form vascular channels replete of erythrocytes a nd some with thrombus, marked pleomorphism, nucleolus evident, binucleated cells and mitotic figures were rare. The immunohistochemistry (IHC) was performed, using streptavidin-biotin peroxidase technique (Dako Cytomation, USA) with the use of antibodies CD31 (clone JC/70A), CD34 (clone QB-END/10). The IHC showed a specific antigen-antibody reaction for CD31. According to localization, morphology and IHC, the present study reports a primary uterine hemangiosarcoma in a spider monkey that caused hemostatic abnormalities and consequent death of the animal.
Highlights
Hemangiosarcoma is a common neoplasm in dogs and less frequently seen in cats
Há relatos de leiomioma uterino em um macaco aranha (Ateles sp.) [1], um rhesus [7] e em chimpanzés [10]
O objetivo deste relato é documentar o primeiro caso de hemangiossarcoma primário intrauterino em macaco aranha de cara vermelha (Ateles paniscus)
Summary
Um macaco aranha de cara vermelha (Ateles paniscus), fêmea, adulto de 17 anos, foi encaminhado, há cinco anos, ao Zoológico Municipal de São Bernardo do Campo com histórico e evidência clínica de um quadro avançado de osteodistrofia, embora adequadamente corrigido, produziu sequelas estruturais. Fragmentos de todos os órgãos foram fixados em formalina tamponada a 10% por 24 horas, cortados em aproximadamente 5 mm, desidratados, diafanizados e incluídos em parafina e, posteriormente, seccionados em cortes de 5 μm de espessura e, finalmente, corados por hematoxilina e eosina (HE). Fragmentos da neoformação uterina, incluídos em parafina foram encaminhados ao Laboratório de Imunoistoquímica do Serviço de Patologia do Instituto Adolfo Lutz de São Paulo. Prosseguiu-se, então, para as etapas de incubação com anticorpo secundário biotinilado genérico (anti-imunoglobulinas de coelho, camundongo e cabra) e, em seguida, com o complexo estreptavidina-biotina-peroxidase.. Valores hematológicos de Ateles paniscus, fêmea, adulta de 17 anos e os valores padrão para o gênero Ateles, São Paulo, 2008
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