Abstract
Background Targeted toxins have the potential to overcome intrinsic or acquired resistance of cancer cells to conventional cytotoxic agents. We hypothesized that EGFuPA-toxin, a bispecific ligand-targeted toxin consisting of a deimmunized Pseudomonas exotoxin conjugated to epidermal growth factor (EGF) and urokinase (uPA), would efficiently target and kill cells derived from canine hemangiosarcoma (HSA), a highly chemotherapy resistant tumor, as well as cultured hemangiospheres, used as a surrogate for cancer stem cells (CSC).
Highlights
Targeted toxins have the potential to overcome intrinsic or acquired resistance of cancer cells to conventional cytotoxic agents
We hypothesized that EGFuPA-toxin
a bispecific ligand-targeted toxin consisting of a deimmunized Pseudomonas exotoxin conjugated to epidermal growth factor
Summary
Jill T Schappa1,2*, Aric M Frantz[1,2], Brandi H Gorden[1,2], Erin B Dickerson[1,2], Daniel A Vallera[2,3], Jaime F Modiano[1,2]. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. 30 September-6 October 2012
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