Abstract
The biological behavior of orbital hemangiopericytoma cannot be determined with certainty microscopically. Because of this lack of correlation between the histopathologic features and clinical outcome, extracted nuclei from 12 hemangiopericytomas of the orbit were studied with flow cytometry in an attempt to determine whether such a study could be used to determine prognosis. Paraffin-embedded blocks were used to perform the nuclear DNA ploidy studies after preparation with the Hedley technique and the Vindeløv method of staining. the clinical records were reviewed with specific attention to surgical details, recurrence, and tumor-related deaths. the flow cytometric DNA ploidy measurements of isolated nuclei showed a diploid pattern in the 12 tumors studied. Thus, this investigation failed to provide prognostic information. Complete surgical removal of the tumor remains an important factor governing the prediction of clinical behavior.
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