Abstract
Mucus form H. aspersa muller has been reported to have several therapeutic proprieties, such as antimicrobial activity, skin protection and wound repair. In this study, we have analyzed H. aspersa mucus (Helixcomplex) bio-adhesive efficacy and its defensive properties against the ozone (O3) (0.5 ppm for 2 hours) exposure in human keratinocytes and reconstructed human epidermis models. Cytotoxicity, tissue morphology and cytokine levels were determined. We confirmed HelixComplex regenerative and bio-adhesive properties, the latter possibly via the characteristic mucopolysaccharide composition. In addition, HelixComplex was able to protect from O3 exposure by preventing oxidative damage and the consequent pro-inflammatory response in both 2D and 3D models. Based on this study, it is possible to suggest HelixComplex as a potentially new protective technology against pollution induced skin damage.
Highlights
Being the skin our first defense against the external world, this organ is continuously exposed to several stressors among which pollution has been shown to be among the most toxic [1,2,3]
Medical examination for conjunctivitis and skin rash were associated with O3 concentrations in a study from 22 cities in France [7]; and we have found positive associations of shortterm O3 concentrations with hospital admissions for skin conditions in multiple areas in Canada [8]
The first step of our study was to evaluate the cytotoxicity of the HelixComplex in human keratinocytes
Summary
Being the skin our first defense against the external world, this organ is continuously exposed to several stressors among which pollution has been shown to be among the most toxic [1,2,3]. The troposphere is characterized by the presence of multiple pollutants, O3 has been shown to be one of the most toxic and recent evidences have supported the idea that O3 is able to affect skin homeostasis and play a role in the development of several skin conditions. Xu et al were able to link skin conditions such as eczema, urticaria, rash/eruption, contact dermatitis, and infection to high 8-hour concentrations of O3 [6]. Medical examination for conjunctivitis and skin rash were associated with O3 concentrations in a study from 22 cities in France [7]; and we have found positive associations of shortterm O3 concentrations with hospital admissions for skin conditions (such as cellulitis, dermatitis, urticaria) in multiple areas in Canada [8].
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