Abstract
Energy calculations have been carried out for several oligomeric peptides derived from β-methyl α-l-aspartate, β-ethyl α-l-aspartate, and β-propyl α-l-aspartate. Self-consistent field calculations have revealed the favored helix sense for such compounds, while self-consistent reaction-field calculations have indicated the influence exerted by the solvent on their conformational preferences. The right-handed α-helix was found to be the most favored conformation for both the ethyl and propyl derivatives. On the contrary, the conformation preferred by the methyl derivatives was the left-handed ω-helix. The influence of the interactions between the amide and ester groups on the helical sense preferences displayed by these compounds are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.