Abstract
To develop a simple and robust helium3 polarization system dedicated to small animal imaging. To demonstrate the potential of helium3 imaging for pulmonary ventilation and perfusion studies. A home-built polarization system based on spin-exchange technique was used. This system was applied for magnetic resonance imaging ventilation studies on rats using a 2-T magnet. Projection-reconstruction sequences combined with the sliding-window technique were used for acquisition of high temporal resolution ventilation images. Helium3 polarization levels up to 25% were obtained. Simultaneous ventilation and lung perfusion images were acquired with intravenous injection of superparamagnetic contrast agents. Dose effects were investigated using several contrast agent concentration values. A tabletop helium3 polarization system was realized. This equipment, which is easy to operate, allows the production of polarized gas appropriate to the requirements of small animal studies. This polarization system was used successfully on a ventilation/perfusion imaging study using intravascular contrast agent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
