Helikobakter pilori eradikasyonunda levofloksasin bazl› rejime C ve E vitamini eklemenin eradikasyon üzerine etkileri

Abstract

Background and Aims: Currently, Helicobacter pylori cannot be eradicated in 100% of patients. In this study, we aimed to evaluate the efficacy of vitamin C and E supplementation on the Helicobacter pylori eradication rate with a levofloxacin-based regimen. Materials and Methods: Seventy patients with Helicobacter pylori -positive nonulcer dyspepsia were randomized into two groups. In group A, patients received lansoprazole 30 mg BID, amoxicillin 1000 mg BID, and levofloxacin 500 mg BID for 14 days; in group B, patients received lansoprazole 30 mg BID, amoxicillin 1000 mg BID, and levofloxacin 500 mg BID for 14 days in combination with vitamin C 500 mg BID and vitamin E 200 IU BID for 30 days. Helicobacter pylori eradication was evaluated with C14 urea breath test 4-6 weeks after the completion of therapy. Results: All patients in both groups completed the therapy. Helicobacter pylori eradication was achieved in 23 of 35 patients (65.8%) in group A and 27 of 35 (77.2%) in group B. The difference was not statistically significant (p=0.404). Conclusions: Helicobacter pylori eradication rates of both regimens were superior to that of standard triple therapy. The eradication rate of levofloxacin-based regimen plus vitamins C and E was close to the acceptable 80% eradication rate. The results of the present study revealed that adjuvant therapies such as vitamins C and E should be added to the eradication regimens.