Abstract
Asthma is a very common respiratory disease which is characterized by the presence of cytokine-mediated airway inflammation leading to smooth muscle contraction, oedema and progressive airway damage in some cases. In light of our recent finding of an increased sero-prevalence of Helicobacter pylori in bronchiectasis, we have determined serum levels of H. pylori -specific IgG in asthmatic and control subjects. Altogether 90 consecutive asthmatic [mean age±SD 42·6±16 years and 52 female (F)] and 97 healthy control subjects (mean age±SD 43·2±13·3 years and 51 female (F);P=0·78 and 0·39 respectively) were recruited prospectively. H. pylori sero-prevalence was not significantly different between asthmatic and control subjects (P>0·05). Serum H. pylori IgG levels did not correlate with FEV1% predicted, FVC % predicted or duration of asthma (P>0·05). Similar to the results of previously published sero-epidemiological studies, there was a weak correlation between serum H. pylori IgG with increasing age (r=0·43, P=0·004). Despite the sero-epidemiological association ofH. pylori infection with many inflammatory conditions, our data showed no such association for middle age asthmatic patients with mild intermittent asthma in our locality.
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