Abstract
We have studied the effect ofHelicobacter pylori (H. pylori) and its bacterial products on mast cell histamine release evoked by compound 48/80, calcium ionophore A 23187 and cholic acid. No significant histamine release is obtained when the various bacterial preparations ofH. pylori are incubated alone with mast cells, but the release of histamine is dose-dependently and significantly enhanced when whole washed and formalin killed cells or crude cell walls are incubated with compound 48/80, calcium ionophore A 23187 or cholic acid. Crude cell walls show the highest activity whereas the filtered supernatants from broth cultures are consistently inactive.
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