Abstract
ObjectiveTo explore potential interactions between folate-cycle factors and Helicobacter pylori seropositivity in the prediction of cognitive function.MethodsWe used data obtained from the 1999–2000 continuous National Health and Nutrition Examination Survey produced by the United States’ Centers for Disease Control and Prevention. Using Ordinary Least Squares regression, we tested for associations between multiple folate-cycle factors, Helicobacter pylori seropositivity, and cognitive function assessed by the digit symbol coding subtest of the Wechsler Adult Intelligence Scale-III. We then tested for interactions between each of the folate-cycle factors and Helicobacter pylori in the prediction of cognitive function.ResultsAlthough Helicobacter pylori seropositivity, 5-methyltetrahydrofolate, vitamin B-12, and homocysteine were not associated with performance on the digit symbol coding task, Helicobacter pylori seropositivity interacted with 5-methyltetrahydrofolate concentration to predict performance on the digit symbol coding task. The Helicobacter pylori seropositive group performed worse on the digit symbol coding task as 5-methyltetrahydrofolate concentration decreased.ConclusionThe interaction between Helicobacter pylori seropositivity and reduced folate-cycle factor 5-methyltetrahydrofolate might impair aspects of cognitive function.
Highlights
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that resides in the gastrointestinal tract of a significant portion of the worldwide population [1]
Helicobacter pylori seropositivity, 5-methyltetrahydrofolate, vitamin B-12, and homocysteine were not associated with performance on the digit symbol coding task, Helicobacter pylori seropositivity interacted with 5-methyltetrahydrofolate concentration to predict performance on the digit symbol coding task
We considered whether interactions between H. pylori seropositivity and methylenetetrahydrofolate reductase (MTHFR) polymorphisms are associated with cognitive function in older adults
Summary
We used data obtained from the 1999–2000 continuous National Health and Nutrition Examination Survey produced by the United States’ Centers for Disease Control and Prevention. We tested for interactions between each of the folate-cycle factors and Helicobacter pylori in the prediction of cognitive function
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