Helicobacter pylori may protect against IBD—a mechanistic insight

Abstract

Helicobacter pylori DNA can suppress the release of proinflammatory cytokines by dendritic cells (DCs) and attenuate the severity of colitis in a mouse model of IBD, new findings show. “There are increasing data suggesting H. pylori protects against chronic inflammatory diseases, such as IBD,” says John Kao, the corresponding author of the study. “The goal of this project was to attempt to define a mechanism for this clinical observation.”