Abstract
Background: Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal.Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori.Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R2 = 0,676. P < 0.001 ).Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.515-520
Highlights
H pylorican causes some clinical manifestation such as chronic gastritis, peptic ulcer disease and gastric malignancies. 4,5 The infection induces infiltration of polymorphonuclear that if nor cleared effectively, than replaced gradually by an immunologically-mediated, chronic, and latter induce pro-inflammatory cytokines production by local or systemic,1,2-6as aresult, gastric epthelium is not the only one target of H pylori pathologic manifestationbut affected to some extradigestive conditions, including endocrine disorders, including autoimmune thyroid disorders (ATD) such
Coefficient TSH serum level and the prevalence of H pylori determinant R2 are 28.09 %. It mean H pylori infection, all subjects were classified into three group infections can causes lower serum lserum level TSH according to their T3 and TSH levels
T3 seum level become more low .Variable age was significantly associated with the risk to decrease T3 serum levels. (Table 6, p < 0.05)
Summary
Helicobacter pylori (H pylori) is a pathogenic bacterium, gram-negative, spiral-shaped that colonizes at the gastric epithelium. 1,2 The prevalence of H pylori infection was 36-41.6 % in Indonesia and more over 50 % of all the world population .2,3 H pylorican causes some clinical manifestation such as chronic gastritis, peptic ulcer disease and gastric malignancies. 4,5 The infection induces infiltration of polymorphonuclear that if nor cleared effectively, than replaced gradually by an immunologically-mediated, chronic, and latter induce pro-inflammatory cytokines production by local or systemic,1,2-6as aresult, gastric epthelium is not the only one target of H pylori pathologic manifestationbut affected to some extradigestive conditions, including endocrine disorders, including autoimmune thyroid disorders (ATD) such. 1. Sri Suwarni, Student at Doctoral Program of Medical Sciences, Faculty of Medicine Sebelas Maret University Indonesia. Pearson Correlationtest had used to determine the association between H pylori infection and T3 and TSH serum level. A total 101 subjects which were elderly population who had visited health promotion center for elderly people called Pos Lansia , enrolled in this study. They were 29 men and 72 women with mean age Tabel 2.
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