Helicobacter pylori inversely related to clinical and functional severity of adult asthma

Abstract

BackgroundHelicobacter pylori (H. pylori) are identified as one of the maximum inducing persistent bacterial infection; about 50% of populations were infected. Many studies detected that H. pylori have the ability for affecting extra-intestinal organs like respiratory system. Aim of the study.is to detect the possible relationship between clinical and functional severity of bronchial asthma and H. pylori infection for better controlling of the disease. Patients and methodsA cross sectional Study carried out at the outpatient clinic of chest department, Zagazig University Hospitals, during the period from February 2015 to December 2015. One hundred and twenty asthmatic patients were selected randomly from bronchial asthma patients attended to outpatient clinic. They were agreed to do spirometry and H. pylori tests. They were (91 females) with mean age ± SD (36.96 ± 5.09) years and (29 males) with mean age ± SD (38.86 ± 4.29) years & with age range from (26–44) years. ResultsThe more degree of severity of bronchial asthma, the less +ve H. pylori cases, with a highly statistically significant difference between +ve and –ve H. pylori as regard severity of bronchial asthma. There was very highly statistically significant difference between mild, moderate, severe persistent asthma as regard H. plylori IgG. (P value < 0.001). Mild asthma were most +ve H. pylori (58.3%), while moderate and severe cases were (31.3%) and (10.4%) respectively. ConclusionH. pylori infection was infrequently associated in asthmatic patients and has a prominent inverse relationship with severity of bronchial asthma and better control of the disease.