Abstract
Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis
Highlights
Long-term treatment of Natalizumab in relapsingremitting multiple sclerosis (MS) (RRMS) patients is associated with the risk of developing progressive multifocal leukoencephalopathy (PML), a JC virus (JCV)-mediated disease of the CNS
Measurement of anti-JCV antibodies in natalizumab-treated MS patients is used for the estimation of patient’s risk for PML and lower percentage of L-selectin CD4 + T cells has been suggested as a biomarker for individual PML risk assessment
The levels of sL-selectin and anti-JCV antibody indices in sera were measured from a total of 99 subjects of whom 44 RRMS patients were treated with natalizumab, 30 patients with IFN-β and 25 subjects were healthy controls
Summary
Optic neuritis is experienced by a majority of multiple sclerosis (MS) patients and is typically characterized by episodes of acute, monocular vision loss. Experimental autoimmune encephalomyelitis (EAE) is a well-established model of MS in which mice are immunized to produce a neuroautoimmunity that recapitulates the cardinal hallmarks of the human disease, namely, increased oxidative stress, demyelination, and neurodegeneration
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