Abstract

Background and study aim: Helicobacter pylori (H. pylori) bacteria convert urea to ammonia, which has been implicated in causation of hepatic encephalopathy(HE) in patients with liver cirrhosis.The aim of this work was to assess the effect of helicobacter pylori infection and its eradication on hepatic encephalopathy. Patients and methods: From March 2010 to November 2011, in Tropical Medicine Department, Zagazig university Hospitals, 90 patients with grade 0-II hepatic encephalopathy were enrolled in the study. The patients diagnosed for hepatic encephalopathy using psychometric tests [number connection test (NCT), and circle connection test( CCT)] and Grading of the symptoms of hepatic encephalopathy was performed, they were evaluated for H. pylori infection (through detection of H. pylori stool Ag) , liver impairment, and blood ammonia concentration. A group of the H. pylori +ve patients were given eradication therapy (triple therapy: 1 wk therapy with omeprazole plus clarithromycin and tinidazole), then patients were revaluated after 2 months using psychometric tests and blood ammonia concentration and compared with untreated group. Results: In our study, the mean level of blood ammonia concentration was significantly higher in H. pylori-positive patients (group II and III: 78.1±9.36 and 82.73±12.22 mmol/L) in comparison to H. pylori-negative patients (group I: 65±17.47 mmol/L ) where P<0.001. Also the time needed to perform NCT and CCT show the lowest mean in H. pylori - negative patients (64.73±13.08 and 35.67±6.66 sec. respectively) in comparison to H. pylori- positive patients with statistically significant difference (P<0.001 for both tests). CCT was significantly reduced in treated and eradicated patients after therapy (30.46±4.9 sec) and shows statistically significant difference (P<0.001) in comparison to untreated or failed to eradicate groups. The blood ammonia concentration in patients with H pylori was significantly reduced after bacterium eradication compared with the concentration after conventional treatment to HE in H. pylori infected controls (49.04± 13.67 vs 61.17±9.81). However, blood ammonia level was reduced in those who received treatment and failed to eradicate in a significant difference from those who didn’t receive eradication therapy (infected controls) (61.17±9.81 vs 75±14.9). Also there was statistically significant difference as regard to hepatic encephalopathy grade pre- and post treatment in infected treated and eradicated group (P=0.04) while there was no statistically significant difference in infected controls or failed to eradicate groups. Conclusion: H pylori infection is an important factor for inducing high blood ammonia concentration in HE patients. Anti-H. pylori therapy results in reduction in blood ammonia levels and may be helpful for treatment and prevention of HE.

Highlights

  • Hepatic encephalopathy is a spectrum of neuro-psychiatric abnormalities in patients with liver dysfunction [1]

  • 90 educated patients with grade 0-II hepatic encephalopathy diagnosed using psychometric tests (NCT and connection test (CCT)) and gading of the symptoms of hepatic encephalopathy is performed. They were grouped depending on diagnosis of helicobacter pylori antigen in stool into 3 groups: non infected group (H. pylori negative), infected group who received treatment for H. pylori eradication and infected group who didn’t receive eradication therapy

  • Our study revealed that blood ammonia level among different groups before treatment showed statistically significant difference in group I (H. pylori negative) (65 ± 17.47 μmol/L) in comparison to group II and III (H.pylori positive) (78.1± 9.36 μmol/L and 82.73±12.22 μmol/L respectively) with P< 0.001.while the blood ammonia level after treatment and 2 months from onset of the study was most reduced in group IIa in comparison to group IIb and III and this reduction was statistically significant (P0.001)

Read more

Summary

Introduction

Hepatic encephalopathy is a spectrum of neuro-psychiatric abnormalities in patients with liver dysfunction [1]. Results: In our study, the mean level of blood ammonia concentration was significantly higher in H. pylori-positive patients (group II and III: 78.1±9.36 and 82.73±12.22 mmol/L) in comparison to H. pylori-negative patients (group I: 65±17.47 mmol/L ) where P

Objectives
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call