Abstract
BackgroundHelicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population.MethodsUsing a case-control approach we studied 617 subjects with 13C-urea breath test (13C-UBT) values ≥10‰ who were defined as being positive for H. pylori (cases), while 617 sex and age- matched subjects with 13C-UBT values ≤1‰ were defined as H. pylori negative (controls) in Beijing Tongren Hospital from March 2016 to May 2017. Biochemical parameters including serum bilirubin and lipids were tested.ResultsA total of 1982 subjects participated in this study. The H. pylori infected subjects had significantly lower serum direct bilirubin concentrations (2.34 ± 0.38 vs. 2.47 ± 0.90 μmol/L, P = 0.008). H. pylori infection was independently associated with lower direct bilirubin levels (OR = 1.497, 95% CI =1.121–1.999, P = 0.006) or total bilirubin levels (OR = 1.322, 95% CI =1.005–1.738, P = 0.046) after adjustment for age, sex, body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglycerides(TG). In addition, the H. pylori infected subjects had higher LDL-C levels (2.98 ± 0.76 vs. 2.89 ± 0.75 mmol/L, P = 0.033) and lower HDL-C levels (1.39 ± 0.37 vs. 1.44 ± 0.41 mmol/L, P = 0.044). LDL-C was negatively correlated with direct bilirubin concentration (R = − 0.260, P < 0.0001).ConclusionsBilirubin has been found to be a potent endogenous antioxidant and negatively associated with metabolic syndrome. Our results suggest that H. pylori infection is an independent risk factor for serum bilirubin reduction and less favorable lipid profiles.
Highlights
Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome
Our results unveiled an intriguing association between bilirubin decrease and H. pylori infection
We doubted if other disorders may influence the bilirubin levels and caused the inauthentic results, we excluded participants with diseases which could affect bilirubin levels pathologically
Summary
Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. H. pylori infection cause upper gastrointestinal diseases including gastritis, peptic ulcer disease and increase the risk of gastric cancer. Several studies suggest that H. pylori infection may influence the gut microbiome [2,3,4]. Diverse extragastric diseases have been linked to H. pylori infection, including dyslipidemia [5], type 2 diabetes [6], insulin resistance [7] and metabolic syndrome [8]. The correlation of H. pylori infection and bilirubin levels has not been reported. H. pylori infection appears to play an important role in the development of metabolic disorders in which require further investigations
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