Abstract
BackgroundThere are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus.MethodsA systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990–March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case–control studies were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis.ResultsA total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR = 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population,ConclusionIn overall a positive association between H. pylori infection and diabetes mellitus was found.
Highlights
There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes
The total sample size in the 41 studies that reported the association between H. pylori infection and the risk of diabetes in case and control was 4327 and 5232, respectively
Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was higher than other population
Summary
There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. This current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. The relationship between H. pylori infection and diabetes was introduced in 1989 [11]. Some case-control studies have reported higher prevalence of H. pylori in patients with diabetes [14, 15]. Several crosssectional studies have shown a significant statistical association between H. pylori and diabetes [3, 15]. Some studies in this regard have shown that there is no significant association between diabetes and prevalence H. pylori infection [2, 16, 17]
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