Abstract
One of the problems of renal disease patients, especially patients undergoing dialysis, is gastrointestinal complications caused by Helicobacter pylori infection. H. pylori has still high prevalence in most populations. It is estimated that about half of the world population is infected with this infection and it can change levels of most micronutrients such as magnesium. Different studies demonstrate that H. pylori may affect the metabolism of magnesium in renal failure. The present paper investigated the association of serum magnesium level with H. pylori infection. Nevertheless, it should be more evaluated by researchers and still many studies are necessary to confirm this issue.
Highlights
Helicobacter pylori is a spiral, highly mobile, gramnegative, and urease-positive bacterium that involves gastric mucosa
Implication for health policy/practice/research/medical education: The present study investigated the association of serum magnesium level with H. pylori infection
The result of the review revealed the association between serum magnesium level and H. pylori infection in renal disease patients
Summary
Helicobacter pylori is a spiral, highly mobile, gramnegative, and urease-positive bacterium that involves gastric mucosa. Considering specific morphology and very fast growth of H. pylori, it penetrates into the viscous mucus layer through pHneutral conditions (Figure 1) [3]. It can be inactive in difficult conditions. Various enzymes of H. pylori such as protease produce a high amount of osmosis that modifies the gastric mucosa and reduces the ability of acid to release more in the mucus [4]. It is known that H. pylori infection has a direct relationship with the reduction of levels of several micronutrients like cobalamin, vitamin A, C, E and B12, copper, and folic acid [4,5,6]. Multiple studies have been indicated an association between H. pylori infection and serum magnesium in renal disease patients that the present study addresses this issue
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