Abstract
Background and Objectives: Helicobacter pylori is linked to gastroduodenal pathologies. To determine the frequency and potential risk factors of the H. pylori infection. Material and methods: A cross-sectional study was conducted, including 227 patients, submitted to upper gastrointestinal endoscopy. A questionnaire was applied to the patients, before endoscopy. The biopsy specimens were obtained from the antrum and gastric body for histology and PCR. The chi-square test was used for the categorical data analysis. P-values 0.05). However, we observed a significant association between the number of persons per household and presence of H. pylori (p=0.04). A statistically significant relation also was found between H. pylori and the patient’s age (p=0.04) and between the histological and endoscopic diagnoses and the H. pylori infection (p≤0.01). Conclusions: We found a significant relation between household crowding and presence of H. pylori, which seems facilitate the person-to-person transmission H. pylori within families. Our results also suggest a cohort phenomenon. The increase in the frequency of H. pylori infection according to age may be due the acquisition of bacterium predominantly in childhood, when the sanitary conditions were deficient, and not during adulthood. Once acquired and untreated, the persistent H. pylori infection might have led to the development of severe gastroduodenal diseases.
Highlights
Knowledge on the interaction between Helicobacter pylori infection and the development of gastric diseases leads to the investigation of its prevalence in different geographic areas
An informed consent was obtained from all patients and a questionnaire was applied for to evaluate the potential risk factors of H. pylori infection
Once H. pylori infection is acquired during childhood, and left unidentified and untreated, it can remain for the entire life, leading to the development of gastric disorders.[5]
Summary
Among the 227 patients included in this study, H. pylori was present in 66.5% (151), which is in accordance with the frequencies reported in the last years in Brazil and other developing countries. Pylori was present in 66.5% (151), which is in accordance with the frequencies reported in the last years in Brazil and other developing countries Since this frequency varies worldwide, mainly due to the socioeconomic level of the population, in developed countries, these rates are lower (~30%). The frequency of H. pylori infection increased with age until the age range of 40–59 years, whereas soon after the frequency decreased This may be associated with a birth cohort effect (i.e. a change in the rate of infection during childhood). HELICOBACTER PYLORI INFECTION AND ASSOCIATED FACTORS Júlia Silveira Vianna, Lande Vieira da Silva Junior, Priscila Cristina B. Thaisa Bozzetti Gauterio, Carolina Alicia Coch Gioia, Andrea Von Grol, Pedro Eduardo A. da Silva, Ivy Bastos Ramis
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