Abstract
Diabetic mellitus patients are usually prone to chronic infections. However, there have been contradictory reports about the association between H. pylori infection and type II diabetes. The present study is aimed at evaluating the prevalence of Helicobacter pylori infection among type 2 dyspeptic diabetic patients in the littoral region of Cameroon. This cross sectional study comprised 93 type 2 diabetic dyspeptic patients and 112 non-diabetic dyspeptic patients attending the Gastroenterology Department at two reference hospitals in Douala-Cameroon. The study was approved by the local Ethical Committee of Medical Sciences. Participants were screened for the presence of both type 2 diabetes and H. pylori infection. Body mass index (BMI) of all the participants was also recorded. Data was analyzed using SSPS statistical package. H. pylori infection was found in 73.11% of diabetic patients versus 58.05% in non-diabetic participants, this difference was found to be significant (OR = 1.472, p = 0.0279). This relationship persists even when adjusted to factors such as age and income level of participants. Infected participants from age group ≥ 55 years and those with high income were those with a higher risk to develop diabetes. Infected patients with high BMI were more prone to develops diabetic mellitus compared with infected patients with normal BMI (p = 0.0034). Also, participant with high BMI were more prone to develops diabetic mellitus whether they were infected or not. Patients having both H. pylori + ve and BMI ≥ 25 kg/m2 were significantly more affected by diabetic mellitus than those in the others combined groups (p < 0.0001), suggested that high BMI and H. pylori infection together or not are factors that favor diabetes mellitus development. Separately or not, H. pylori infection and high BMI were risk factor for diabetes mellitus in our milieu.
Highlights
Diabetic mellitus patients are usually prone to chronic infections
Ricci et al after investigation reported that upper gastrointestinal tract symptoms similar to those associated with Helicobacter pylori (H. pylori) infection are more common in patients with diabetes than in individuals with no diabetes[5]
We found if high Body mass index (BMI), H. pylori infection alone or together are associated with diabetes status
Summary
Diabetic mellitus patients are usually prone to chronic infections. there have been contradictory reports about the association between H. pylori infection and type II diabetes. The present study is aimed at evaluating the prevalence of Helicobacter pylori infection among type 2 dyspeptic diabetic patients in the littoral region of Cameroon. Regarding statistics from the World Health Organization (WHO), the most common type of diabetes is type 2 diabetes mellitus (DMT2) with about 90% of diabetic patients suffering from this type[1]. Ricci et al after investigation reported that upper gastrointestinal tract symptoms similar to those associated with Helicobacter pylori (H. pylori) infection are more common in patients with diabetes than in individuals with no diabetes (controls)[5]. The aim of this study was to evaluate the prevalence of H. pylori infection in DMT2 dyspeptic patients in Cameroon For this purpose, data was analyzed from participants attended two public hospitals in Douala metropolis; Laquintinie Hospital and Bonassama District Hospital for dyspepsia. A good understanding of the role of H. pylori in diabetes mellitus could be useful in terms of prognosis and management of the disease
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