HELICOBACTER PYLORI IN GASTRIC CANCER

Abstract

ObjectiveHelicobacter pylori (Hp) has a dominan role in gastroduodenale diseases i.e chronic active gastritis peptic ulcer and gastric cancer. The prevalence of gastric cancer in Indonesia from upper GI endoscopy examinations was 1.33‐4.2%. The prevalence of Hp infection in gastric cancer worlwide is between 52 ‐ 94%. Hp infection may lead chronic active gastritis to be dysplasia and then carcinoma. The aim of this study is to find the prevalence of Hp infection in gastric cancer, the relation between Hp and gastric cancer.Material & MethodsThe gastric cancer cases who were treated in Ciptomangunkusumo hospital and Abdiwaluyo hospital in 2 years (1998‐1999) were included in this study. As control we included chronic gastritis cases in the same years and same hospital. All of the patients were done endoscopical examination, mucosal biopsy for pathological examination or CLO test and serum Hp serology examination (IgG Helicobacter pylori). Hp infection was thought to be positive if minimally the pathological examination positive or both of CLO test & Hp serology positive. Exclusion if incomplete data, the patient refused to follow the study. Statistic chi‐square test or fisher test.ResultWe got 21 cases of gastric cancer and 78 cases of chronic gastritis. The most frequent characteristic of gastric cancer patients was age group 50‐59 yo(38.09%), male(80.95%), batak ethnic(38.09%), blood A group (50%). The symptom of the patients were upper GI bleeding (42.85%), abdominal mass (66.66%). Hp was positive in 17/21(80.95%) of gastric cancer patients and 17/78(21.79%) of chronic gastritis patients, respectively (p=0.000001).Hppositive in adenocarcinoma (52.38%), signet ring cell carcinoma (19.04%), carcinoid tumor (4.76%) & malt lymphoma (4.76%).ConclusionHp infection is very frequent in gastric cancer.