Abstract
BackgroundHelicobacter pylori, a gram-negative bacterium, can cause gastritis, peptic and duodenal ulcers. It is considered an important public health problem for both developed and developing world. This bacterium is classified as the class 1 carcinogen because it can cause cancer.MethodsA hospital based study was conducted at Chitwan Medical College Teaching Hospital (CMCTH) from May to October 2014. Stool samples were collected from the suspected patients and were subjected to detection of the H. pylori stool antigen (HpSAg) following the procedures recommended by the manufacturer. A standard questionnaire on the potential risk factors was also designed and completed.ResultHpSAg was detected in 16 % of suspected patients. The children up to 10 years of age were found to be highly infected (36 %). The patients living in urban area were found more susceptible to develop H. pylori infection (P < 0.05). Tea drinking and repeated eating habit (more than twice a day) were listed as the important factors that can limit the H. pylori infections significantly (P < 0.05).ConclusionIn this hospital based study, a significant rate of prevalence was evaluated. However, we recommend a community based extensive study to reveal the real scenario of H. pylori infection in Nepalese populations.
Highlights
Helicobacter pylori, a gram-negative bacterium, can cause gastritis, peptic and duodenal ulcers
We recommend a community based extensive study to reveal the real scenario of H. pylori infection in Nepalese populations
Socio‐demographic risk factors and H. pylori colonization Among the several socio-demographic risk factors assessed in this study, the age up to 20 years, females by gender, people with large family (5–10 members) and education up to primary level were found to have contributions in higher rate of colonization but the association was non-significant (P > 0.05)
Summary
Helicobacter pylori, a gram-negative bacterium, can cause gastritis, peptic and duodenal ulcers. It is considered an important public health problem for both developed and developing world. This bacterium is classified as the class 1 carcinogen because it can cause cancer. Helicobacter pylori (H. pylori), established in 1982 by Robin Warren and Barry Marshall as the causative agent of gastritis and peptic ulcer, is a spiral, Gram-negative, micro-aerophilic bacterium [1, 2]. Before the discovery of Warren and Marshall, the human stomach was believed to be a sterile area but H. pylori is recognized as the most common cause of gastritis, which can lead to the development of more severe gastrointestinal complications such as peptic and duodenal ulcers. The H. pylori is a public health problem in both developed and developing countries [8], its annual
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