Abstract
Gastric cancer (GC) is the third most common cancer regarding mortality in the world. The cag pathogenicity island (PAI) of Helicobacter pylori which contains genes associated with a more aggressive phenotype may involve in the pathogenesis of gastrointestinal disease. We here aimed to examine the associations of cagH, cagL, orf17, and cagG genotypes of H. pylori cag PAI with severe gastrointestinal disease. A total of 242 H. pylori strains were genotyped. Histopathological examination and classification of subjects were performed. The frequencies of the cagH, cagL, cagG, and orf17 genotypes were 40/54 (74.1%), 53/54 (98.1%), 38/54 (70.4%), and 43/54 (79.6%), respectively, in patients with peptidic ulceration (PU),while in the control group, the frequencies were 87/147 (59.6%) for cagH, 121/146 (82.9%) for cagL, 109/146 (74.7%) for cagG, and 89/146 (61.0%) for orf17. The results of simple logistic regression analysis showed that the cagL and orf17 genotypes were significantly associated with an increased risk of PU not GC; the ORs (95% CI) were 10.950 (1.446-82.935), and 2.504 (1.193-5.253), respectively. No significant association was found between the cagH and cagG genotypes and the risk of both the PU and the GC in Iran (P>0.05). Finally, multiple logistic regression analysis showed that the cagL genotype was independently and significantly associated with the age- and sex-adjusted risk for PU; the OR (95% CI) was 9.557 (1.219-17.185). We conclude that the orf17 and especially cagL genotypes of H. pylori cag PAI could be factors for risk prediction of PU, but not GC in Iran.
Highlights
Gastric cancer (GC) is the third common cancer that ends up death in the world* with different incidence rate based on geographical areas (Parkin, 2004)
We conclude that the orf17 and especially cagL genotypes of H. pylori cag pathogenicity island (PAI) could be factors for risk prediction of peptidic ulceration (PU), but not GC in Iran
The presence of H. pylori in the gastric mucosa has been known as an essential risk factor of different gastrointestinal disease including; Non-atrophic gastritis (NAG), PU, and GC
Summary
Gastric cancer (GC) is the third common cancer that ends up death in the world* with different incidence rate based on geographical areas (Parkin, 2004). Several studies have been shown that interaction between host and environmental factors, especially Helicobacter pylori (H. pylori) infection may play a remarkable role (Covacci et al, 1993; Atherton et al, 1995; Peek and Blaser, 2002; Yamaoka, 2010) This bacterium is found in more than 50 % of the world population and it is a well-known human pathogen. We here aimed to examine the associations of cagH, cagL, orf, and cagG genotypes of H. pylori cag PAI with severe gastrointestinal disease. Conclusions: We conclude that the orf and especially cagL genotypes of H. pylori cag PAI could be factors for risk prediction of PU, but not GC in Iran
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