Abstract
BackgroundDespite the high prevalence of Helicobacter pylori infection in Nigeria, in the North-West there are no studies on the antibiotic sensitivity pattern of this organism. This study aims to determine the antibiotic sensitivity pattern of this bacterium as well as bridge the gap in knowledge.MethodsThe study was cross-sectional in design. Questionnaires were administered in dyspeptic patients to obtain the relevant data. Two sets of gastric biopsy specimens were taken during upper gastrointestinal (GI) endoscopy. One set was sent to the histopathology laboratory for assessment and H. pylori identification, while the other set for culture was minced and plated on Columbia blood agar media (Oxoid Ltd, England) incubated at 37°C in an anaerobic jar containing CampyGen (Oxoid Ltd) to provide the required micro-aerobic environment. The disc diffusion method was used in determining the sensitivity pattern of isolates. Pre-treatment and post-treatment stool samples were collected from each patient for a H. pylori faecal antigen test to assess eradication rate.ResultsThe sensitivity of H. pylori to amoxicillin was 9.2%, and 100% for both clarithromycin and levofloxacin. Tetracycline, metronidazole, cefuroxime, tinidazole and ciprofloxacin were 100% resitant. The prevalence of H. pylori at histology was 81.7%. Only 101 subjects had a positive H. pylori stool antigen test.ConclusionThis study showed a high amoxicillin resistance; however, there is high sensitivity (100%) to clarithromycin and levofloxacin. We recommended that levofloxacin be adopted in preference to amoxicillin as part of triple therapy in Nigeria.
Highlights
Helicobacter pylori is the most important aetiologic risk factor of peptic ulcer disease (PUD) that infects human gastric tissue in half of the world’s population
There is a high prevalence of H. pylori in resource-poor regions of the world, in Africa, which has the highest burden of the infection.[1,2,3]
In a study conducted in Jos, North-central Nigeria, in 1999, H. pylori sensitivity to amoxicillin and clarithromycin was reported as 100% and 87.3%, respectively.[4]
Summary
Helicobacter pylori is the most important aetiologic risk factor of peptic ulcer disease (PUD) that infects human gastric tissue in half of the world’s population. This study was designed to determine the in vitro sensitivity pattern of H. pylori obtained from dyspeptic patients undergoing diagnostic oesophago-gastro-duodenoscopy (OGD) at Aminu Kano Teaching Hospital (AKTH), Kano, Nigeria. The study is intended to bridge the gap and to contribute to the growing interest and knowledge in H. pylori, and to assist physicians in the choice of appropriate antibiotics for H. pylori eradication. Despite the high prevalence of Helicobacter pylori infection in Nigeria, in the North-West there are no studies on the antibiotic sensitivity pattern of this organism. This study aims to determine the antibiotic sensitivity pattern of this bacterium as well as bridge the gap in knowledge
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