Abstract
EnBackgroundHelicobacter pylori causes several gastric, intestinal, and extraintestinal manifestations. It also causes persistent infection and can cause serious various hematological effects.AimsTo investigate the hematological effect of H. pylori infection.Patients and methodsThis is a cohort study that included 50 adult (age range: 18–75 years) patients infected with H. pylori and 50 adult patients who presented with symptoms suggestive of gastritis. All patients underwent upper endoscopy, and biopsies were taken. Moreover, the patients underwent complete blood count, iron studies, hepatitis C virus antibodies, vitamin B12 level, and bone marrow aspirate.ResultThe results showed that hemoglobin level, serum iron level, vitamin B12 levels, and platelets count were much lower in patients infected with H. pylori than the control group.ConclusionH. pylori causes iron-deficiency anemia, vitamin B12 deficiency, and thrombocytopenia, and treatment of H. pylori causes much improvement in these parameters.
Highlights
Helicobacter pylori is one of the most common infection in humans
Our study showed there was a significant decrease in Regarding family history of H. pylori infection, our vitamin B12 level and folic acid in study showed there was a significant increase in
Our study showed no significant correlation between age and occurrence of hematological problems with H. pylori infection, which differs from Schwarz et al [16]
Summary
Helicobacter pylori is one of the most common infection in humans It causes several gastric, intestinal, and extragastric manifestations. H. pylori causes chronic gastritis, peptic ulcer, gastric mucosaassociated lymphoid tissue lymphoma, and gastric adenocarcinoma [1]. It causes more than 50 extragastric manifestations, including cardiac, dermal, endocrinal, gynecological, obstetrical, pneumatology, neurological, ophthalmological, and hematological ones [2]. Our study is only concerned with hematological manifestations, including iron-deficiency anemia, vitamin B12 deficiency, and immune thrombocytopenia. Helicobacter pylori causes several gastric, intestinal, and extraintestinal manifestations. It causes persistent infection and can cause serious various hematological effects. Conclusion H. pylori causes iron-deficiency anemia, vitamin B12 deficiency, and thrombocytopenia, and treatment of H. pylori causes much improvement in these parameters
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