Abstract
The modern Gastroenterology have witnessed an essential stride since Helicobacter pylori was first found in the stomach and then its pathogenic effect was discovered. According to the researches conducted during the nearly 40 years, it has been found that this bacterium is associated with a natural history of many upper gastrointestinal diseases. Epidemiological data show an increased incidence of autoimmune disorders with or after infection with specific microorganisms. The researches have revealed that H. pylori is a potential trigger of gastric autoimmunity, and it may be associated with other autoimmune diseases, both innate and acquired. This paper reviews the current support or opposition about H. pylori as the role of potential triggers of autoimmune diseases, including inflammatory bowel disease, autoimmune thyroiditis, type 1 diabetes mellitus, autoimmune liver diseases, rheumatoid arthritis, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, as well as Sjogren’s syndrome, chronic urticaria and psoriasis, and tried to explain the possible mechanisms.
Highlights
AND EPIDEMIOLOGYHelicobacter pylori has been co-evolving with humans for more than 60,000 years [1], and it was first isolated from stomach biopsy in 1983 by Marshall and Warren [2]
The current paradigm for the development of autoimmune diseases is understood to be that they are triggered by exposure of genetically susceptible individuals to environmental factors [163]
According to the studies above, we can confirm that the infection of H. pylori is a significant one among many environmental factors which lead to many types of autoimmune diseases
Summary
Helicobacter pylori has been co-evolving with humans for more than 60,000 years [1], and it was first isolated from stomach biopsy in 1983 by Marshall and Warren [2]. It has been proved that the poor living conditions in childhood is the crucial risk factor for people to get infected by H. pylori [5]. H. pylori is generally transmitted from mouth to mouth and feces to mouth, and contaminated water supplies may be another source of transmission [7]. It is mainly obtained in childhood and is likely to last for a life time of the host [8]. Childhood spontaneous remission is relatively common but it’s often associated with diseases treated with antibiotics [9]. The treating methods of H. pylori mainly include triple therapy, sequential therapy, bismuth therapy, vonoprazan, probiotics, vaccines, etc. The treating methods of H. pylori mainly include triple therapy, sequential therapy, bismuth therapy, vonoprazan, probiotics, vaccines, etc. [11] But some current problems such as antibiotic resistance and high recurrence rate still need to be concerned
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
