Helicobacter pylori and atrophic gastritis

Abstract

Infection with Helicobacter pylori plays a crucial role in the etiology of atrophic gastritis and gastric cancer. Studies suggest a nine-fold increased risk for both conditions in the presence of infection. The risk of atrophic gastritis in the presence of infection is dependent upon the severity of the gastritis. Gastritis is increased in subjects infected with a cytotoxic H pylori strain and in those with a decreased acid production. The development of atrophy may be related to the induction of cross-reacting antibodies recognizing Lewis epitopes on H pylori lipopolysaccharide and gastric mucosa. Future studies have to demonstrate whether atrophic gastritis and gastric cancer can be prevented by early H pylori eradication.