Abstract
Helichrysum cymosum is a valuable and well-known medicinal plant in tropical Africa. The current study critically reviewed the medicinal uses, phytochemistry and biological activities of H. cymosum. Information on medicinal uses, phytochemistry and biological activities of H. cymosum, was collected from multiple internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information was gathered from pre-electronic sources such as journal articles, scientific reports, theses, books, and book chapters obtained from the University library. This study showed that H. cymosum is traditionally used as a purgative, ritual incense, and magical purposes and as herbal medicine for colds, cough, fever, headache, and wounds. Ethnopharmacological research revealed that H. cymosum extracts and compounds isolated from the species have antibacterial, antioxidant, antifungal, antiviral, anti-HIV, anti-inflammatory, antimalarial, and cytotoxicity activities. This research showed that H. cymosum is an integral part of indigenous pharmacopeia in tropical Africa, but there is lack of correlation between medicinal uses and existing pharmacological properties of the species. Therefore, future research should focus on evaluating the chemical and pharmacological properties of H. cymosum extracts and compounds isolated from the species.
Highlights
Helichrysum cymosum (L.) D.Don is a member of the Asteraceae or Compositae family, commonly referred to as aster, daisy, or sunflower family
Research by Jeschke et al [4] showed that the family Asteraceae has at least 420 known medicinal species and these include Arnica montana L. [5,6,7,8,9,10,11], Artemisia annua L. [12,13,14,15,16,17,18,19], Calendula officinalis L. [20,21,22,23,24,25], Chamaemelum nobile (L.) All. [26,27,28,29,30], Inula helenium L. [31,32,33,34,35,36], and Matricaria recutita L. [37,38,39,40,41,42,43]
The current study is aimed at providing a critical appraisal of the existing ethnomedicinal value, phytochemistry and biological activities of H. cymosum, as well as exploring the potential of the species as herbal medicine in tropical Africa
Summary
Helichrysum cymosum (L.) D.Don is a member of the Asteraceae or Compositae family, commonly referred to as aster, daisy, or sunflower family. Van Vuuren et al [89] and Van Vuuren [94] evaluated the antibacterial activities of acetone extracts of aerial parts of H. cymosum, essential oil and compound helihumulone isolated from the species against Enterococcus faecalis, B. cereus, B. subtilis, S. aureus, P. aeruginosa, Yersinia enterocolitica, and E. coli using disc diffusion and microdilution techniques with ciprofloxacin as a positive control. Reddy [85] evaluated antibacterial activities of acetone and methanol extracts of aerial parts of H. cymosum as well as essential oils isolated from the species against E. coli, Yersinia enterocolitica, Klebsiella pneumoniae, S. aureus, and B. cereus using disc diffusion assay with ciprofloxacin (0.01 mg/ml) as a positive control.
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