Abstract
The introduction of a five-membered ring α,α-disubstituted α-amino acid into l-Leu-based heptapeptides preferentially induced right-handed (P) helical structures. Using 5 ∼ 20 mol% of a single helical foldamers-catalyst, enantioselective 1,4-addition reactions of dialkyl malonates to cycloalk-2-enones (5 ∼ 7 rings) proceeded to give chiral 3-substituted cycloalkanones with 94 ∼ 99% ee in moderate chemical yields, regardless of the ring size of substrates.
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