Height at Ages 7-13Years in Relation to Developing Type 2 Diabetes Throughout Adult Life.

Abstract

Short adults have an increased risk of type 2 diabetes. Although adult height results from childhood growth, the effects of height and growth trajectories during childhood are sparsely investigated. We investigated sex-specific associations between childhood height, growth and adult type 2 diabetes, including potential influences of birthweight and childhood body mass index (BMI). We followed 292827 individuals, born 1930-83, from the Copenhagen School Health Records Register in national registers for type 2 diabetes (11548 men; 7472 women). Weights and heights were measured at ages 7-13years. Hazard ratios (HR) of type 2 diabetes (age ≥30years) were estimated without and with adjustment for birthweight and BMI. In men, associations between height and type 2 diabetes changed from inverse for below-average heights at age 7years to positive for above-average heights at 13years. No consistent associations were observed among women. These associations were not affected by birthweight. After adjustment for BMI, below-average childhood heights were inversely associated with type 2 diabetes among men (HR range: 0.91-0.93 per z-score) but above-average heights were not. Among women, after adjustment for BMI, below- and above-average heights in childhood were inversely associated with type 2 diabetes (HR range: 0.91-0.95). Greater height growth from 7 to 13years was positively associated with type 2 diabetes in men and women. After adjustment for BMI, short childhood height at all ages and greater growth during childhood are associated with an increased risk of type 2 diabetes, suggesting that this period of life warrants mechanistic investigations.