Heg lnc RNA and Cdk1 mRNA in mononuclear cells and regulation of autoantibody levels

Abstract

We studied Heg lnc RNA and Cdk mRNA in mononuclear cells in untreated and treated patient with Graves disease and in normal subjects Heg was inversely correlated with TRAb in untreated patients and inversely correlated with CD mRNA in treated patients and in normal subjects These and other findings suggest that endogenous Heg may reduce expression of CD mRNA and thereby reducing inflammation and autoantibody levels The concentration of Cdk mRNA decreased during Thiamazole treatment Concentrations of TRAb decreased correspondingly Conclusions These and other findings indicate that Heg lnc RNA and Cdk have an effect on autoantibody levels achieved without affecting the risk of developing autoimmune disease Our results also support the hypothesis that inhibition of Cdk or CK by new drugs may inhibit the production of autoantibodies and autoimmunity in the organism