Abstract
Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O2− and HClO with its Fe2N6O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H2O2 (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies.
Highlights
Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA)
To mimic the “capture and killing” function of macrophages both from the surface topography and reactive oxygen species (ROS) generation capability, we designed a micron-sized hedgehog particle doped with Fe-Nx or V-Nx based atomic catalytic centers (Fig. 1d)
In summary, our finding demonstrates that the synthesized hedgehog Art M with atomic-catalytic centers is an ideal material to combat MRSA and can mimic the “capture and killing” process of natural macrophage
Summary
Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies. It is a crucial challenge to develop ROS catalytic materials that can simultaneously mimic the “capture and killing” process of macrophages to combat bacteria, especially integrated with heme-mimetic catalytic sites To address this challenge, we present here the design of a hedgehog artificial macrophage with heme-mimetic atomic-catalytic centers to combat MRSA. The experimental studies and theoretical calculations reveal that the synthesized artificial macrophage can efficiently capture and kill MRSA by the hedgehog topography and localized massive generation of O2− and HClO with its Fe2N6O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H2O2 (100 μM)) to combat MRSA and can rapidly promote the healing of bacteria-infected wounds on rabbits skin, which is comparable to the treatment efficiency of vancomycin
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