Abstract
Various conditions have been tested to obtain efficiently 2-methyl-1-indanone via the Pd-catalyzed 5- endo- trig cyclization of 1-( o-bromophenyl)-2-methylprop-2-en-1-ol. High yield (97%) was obtained at 120 °C in DMF with Pd(OAc) 2/cinchonine as the catalytic system and NaHCO 3 as the base. Use of this procedure for the synthesis of other substituted indanones led to lower yields but replacing thermal heating by microwave heating improved greatly the results.
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