Abstract
Abstract Heavy metals are ubiquitous environmental contaminants that are capable of inducing a broad range of physiological, biochemical and behavioural dysfunctions. Heavy metal poisoning remains a persistent public health problem in Malaysia and throughout the world. Exposure to toxic metals and compounds containing them through inhalation, ingestion or skin contact may cause various pathophysiological conditions, and the nervous system is the most susceptible organ system to this exposure causing a condition known as heavy metal-mediated neurotoxicity. This review summarises the current understanding of the mechanisms by which arsenic, lead and mercury induce heavy metal-mediated neurotoxicity. These heavy metals cause toxic manifestations in the nervous system primarily through the presence of excessive pro-oxidants and depletion of antioxidants, causing an imbalance homeostasis also described as oxidative stress. In addition, this article also reviews previous common chelation treatments and emerging antioxidant treatments since antioxidants have become the current interest in the prevention and treatment of these heavy metal-mediated toxicities.
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