Abstract
The tumorigenic effects of galactic cosmic rays (GCR) have become a major concern to the members of the international space station program. Normal human small airway epithelial cells were immortalized by ectopic expression of hTERT. The hTERT-expressing cells were exposed to 56Fe ions which simulate GCR irradiation. The irradiated cells underwent a stepwise transformation process. They showed phenotypic alterations and loss of some chromosomes compared with control hTERT-expressing cells.
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