Abstract
Heat-shocks (10 and 30 min at 40°C) prior to treatment with MH or TEM significantly reduced the yield of metaphases with chromatid aberrations. No such effect was observed when ethanol was used for aberration induction. The ‘heat-shock effect’ on aberration induction by MH and TEM is comparable to ‘clastogenic adaptation’ observed after pretreatment (‘conditioning’) with low clastogen concentrations prior to ‘challenging’ with high clastogen concentrations; both require unimpaired protein synthesis.
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