Heat Transfer in Biological Spherical Tissues during Hyperthermia of Magnetoma.

Mahmoud Ragab,Huda F Alshaibi,Rasha A Mansouri,Ahmed E Abouelregal

doi:10.3390/biology10121259

Mahmoud Ragab, Huda F Alshaibi + Show 2 more

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https://doi.org/10.3390/biology10121259

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Abstract

Simple SummaryHeat transport in biological tissue is mediated through a variety of phenomenological processes, involving tissue heat exchange, blood-tissue convection, blood perfusion or advection and diffusion across microvascular beds, and metabolic heat production. In recent years, many physicians and engineers have taken an interest in applying computational and mathematical techniques to model biological systems. The objective of the current paper is to provide an analytical solution to the modified Pennes bioheat conduction equation with a single relaxation time. The suggested model is used to examine heat transport in biological tissues as an infinite concentric spherical region during magnetic fluid hyperthermia. This method is used to investigate the influence of heat generation through heat treatment on a skin tumor a spherical layered structure. The present model can explain the effect of different therapeutic approaches such as cryotherapy sessions, laser therapy, and physical occurrences including transfer, metabolism support, blood perfusion, and other similar treatments.Hyperthermia therapy is now being used to treat cancer. However, understanding the pattern of temperature increase in biological tissues during hyperthermia treatment is essential. In recent years, many physicians and engineers have studied the use of computational and mathematical models of heat transfer in biological systems. The rapid progress in computing technology has intrigued many researchers. Many medical procedures also use engineering techniques and mathematical modeling to ensure their safety and assess the risks involved. One such model is the modified Pennes bioheat conduction equation. This paper provides an analytical solution to the modified Pennes bioheat conduction equation with a single relaxation time by incorporating in it the (MGT) equation. The suggested model examines heat transport in biological tissues as forming an infinite concentric spherical region during magnetic fluid hyperthermia. To investigate thermal reactions caused by temperature shock, specifically the influence of heat generation through heat treatment on a skin tumor [AEGP9], the Laplace transformation, and numerical inverse transformation methods are used. This model was able to explain the effects of different therapeutic approaches such as cryotherapy sessions, laser therapy, and physical occurrences, transfer, metabolism support, and blood perfusion. Comparison of the numerical results of the suggested model with those in the literature confirmed the validity of the model’s numerical results.

Highlights

Hyperthermia is a highly interesting topic in medicine
We present some numerical results to clarify our theoretical conclusions in the previous part and to show the impact of the blood perfusion rate and thermal relaxations on the temperature change
The (MGT) equation is included in the modified Pennes bioheat conduction equation with a single relaxation time, and its impacts are shown in thermal treatment applications

Summary

Introduction

Several studies have been conducted on the use of heat transmission to living tissues for cancer treatment [1] as well as to enhance treatment procedures and create more sophisticated and precise technologies for forecasting temperature in biological tissues. Such studies have led to the development and use of hyperthermia therapy, known as “thermal medicine” or “thermotherapy,”. Hyperthermia can be used to treat a specific area of the body or the entire body It is used in conjunction with standard treatments and is available only through referral and under the supervision of a healthcare practitioner [2].

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