Abstract
A heat shock applied at the blastoderm stage to Drosophila embryos produces phenocopies of dominant mutants of the bithorax-complex (BX-C). We have studied the effect of different genetic variations upon the frequency of Ultraabdominal phenocopies. The results indicate that heat shock acts upon regulation rather than expression of the BX-C. They are also in accordance with the possible role of Polycomb and a gene included in Deficiency (3) red in the regulation of BX-C. We postulate that the actual repression of the Ultraabdominal locus is due to at least two factors, one governed by the wild-type allele of the Polycomb locus and one governed by the BX-C itself. The results suggest that the heat shock interferes with the BX-C factor and not with the product of Polycomb.
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