Heat shock proteins - participants in osteoarthrosis pathogenesis

Abstract

Osteoarthrosis is a disease that affects all tissues of synovial joints, resulting in chronic pain and often a need for replacement. The high prevalence and the lack of reliable conservative approaches impose significant economic sanctions on most economies in the world. Currently the mechanisms of osteoarthrosis progression have been well studied. At the same time, the known pathogenetic concepts do not allow to define reliable targets of conservative treatment. There is a clear need for searching alternative concepts, which will help to expand the understanding of the pathogenesis and identify ways to address therapeutic issues. Heat shock proteins (chaperones) are involved in intra- and extracellular signaling in the pathogenesis of many diseases. The aim of this review is to analyze the current state of the problem of studying the role of heat shock proteins in the pathogenesis of osteoarthrosis. The review considers the fundamental aspects of the activation and functioning of chaperones, experience of studying chondrocyte heat shock proteins is described, issues of programmed cell death mechanisms are mentioned, scheme of shaperone activity in osteoarthrosis is illustrated. The role of heat shock proteins from the perspectives of reparation and alteration carried out in the articular cartilage is described, the prospects for further clarification of their role in the pathogenesis of osteoarthrosis are identified. The role of two key molecules - protein with molecular weight of 70 kD and a small molecule with molecular weight of 27 kD, is emphasized. Heat shock proteins are of fundamental and applicative interest from the perspective of their participation in the key ways of osteoarthrosis pathogenesis and phenomena (oxidative, microcrystalline, hydrodynamical, stress, aging, etc.). Further study of heat shock proteins will allow to significantly expand the knowledge of osteoarthrosis and to identify ways of targeted therapy.