Abstract
Heat-Shock Proteins in Autoimmunity
Highlights
Heat shock proteins (HSPs) are highly conserved in nature, and they are quite immunogenic
Defined pathogenic versus regulatory T- or B-cell epitopes have been identified within the same HSP, for example HSP60/65
During the course of autoimmunity, epitope spreading or diversification of response can lead to induction of new T-cell/antibody responses, which in turn may aggravate or downmodulate autoimmunity depending on the antigenic epitopes targeted in the process. Several papers in this special issue discuss the pathogenic role of HSP-induced immunity
Summary
HSPs are highly conserved in nature, and they are quite immunogenic. These attributes may render these proteins as initiators of immune response as well as targets of autoimmune attack. These papers cover the role of HSPs in antigen cross-presentation, induction of autoimmunity, and immunotherapy of autoimmunity/cancer Calderwood et al.); the role of HSPs in the pathogenesis of the autoimmune components of diverse diseases including atherosclerosis Dickinson); and HSP-induced regulatory T cells and their role in control of autoimmunity
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