Abstract

Objectives: Previously we showed the following about Heat Shock Protein 27 (HSP27): i) Increasing serum levels either via over-expression (HSP27o/e mice), bone marrow transplantation or recombinant HSP27 (rHSP27) injection attenuate de novo atherogenesis, and ii) low serum levels represent a novel biomarker for human atherosclerotic events (MI, CVA, Death). We now test the ability of rHSP27 to modulate the progression of established atherosclerotic lesions.

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