Abstract
We investigated the association between heat‐induced stress responses and heat tolerance levels in mice. Thirty‐eight mice were assigned into control and three heat exposure groups ‐ tolerant (TOL), moderately tolerant (MT) and intolerant (INT), based on their thermal responses. Real‐time core temperature, blood pressure, and heart rate were assessed during heat exposure (120 min at 39.5°C) under conscious condition. Tissue samples were collected 18–22 hours following heat exposure. INT mice had significantly higher peak mean arterial pressure and heart rate than TOL mice during heat exposure. Plasma corticosterone levels were significantly higher in INT than control mice. No changes in plasma cytokines or markers of oxidative status were observed. INT mice showed significant increases in HSP72 and HSP90 protein and mRNA levels in liver, heart and gastrocnemius muscles compared to TOL and control mice. In contrast, INT mice had significantly lower HSF1 and glucocorticoid receptor protein and mRNA levels in these tissues than TOL and control mice. These results suggest that heat exposure causes an extensive stress response in mice with heat intolerance. Complex transcriptional and translational processes are involved in mediation of heat‐induced stress. (supported by ONR N0001411MP20025 and USUHS R091EH)
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