Abstract
Solid dispersions and mixtures of quercetin and poly(vinylpyrrolidone) (PVP) K30 are studied by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and heat capacity (Cp) measurements. The IUPAC name for PVP is 1-ethenylpyrrolidin-2-one, and that for quercetin is 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one. A solid dispersion is found in the region of w1 < 0.5, and a solid mixture is found in the region of w1 > 0.5, where w1 is the mass fraction of quercetin. The Cp data is correlated to temperature T by a polynomial equation, and changes in enthalpy and entropy were calculated from Cp. The Cp data is valuable in the evaluation of drug efficiency.
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