Heart-Type Fatty Acid Binding Protein as Potential Biomarker for Acute Myocardial Infarction

Abstract

Acute myocardial infarction (AMI) is the most recurrent heart emergency which can lead to morbidity and death. During infarction, the heart releases cytoplasmic protein in the blood. These proteins such as creatine kinase, troponin and Heart type fatty acid binding protein (H-FABP) are used as indicators to spot cardiovascular arrest. This research paper aims to evaluate the efficiency, specificity and sensitivity of biomarkers in determining the AMI. This paper shows the use of direct sandwich ELISA technique to determine the level of H-FABP released in early stage of AMI. 50 suspected AMI subjects were used to observe the specificity, sensitivity and diagnostic efficacy. The study also discusses the correlation of the concentration of H-FABP in confirmed AMI, non AMI and normal subjects.