Abstract
lowed. Responses were compared to an untreated control group. Results: 100% peripheral and 99% centrally located CD19 / CD20 B-cells were ablated with anti-CD20 monoclonal antibody therapy. Some baboons expericed a transient decrease in anti-Gal 1– 3Gal IgM titers. Responses were partially sustained. Treated baboons exposed to PRBC responded appropriately with anti-Gal 1–3Gal IgM/IgG antibody production. These responses occured despite effectiveCD19 /CD20 B-cell ablation. With a rise in antibody titers a concomitant rise in the percent of CD19-/CD20-/IgM( ) and CD19 /CD20 /IgG B-cells occurred. Conclusion: Taken together, these findings suggest that the repertoire of B-cells responsible for naturally occuring xenoreactive antibodies is comprised of CD20 B-cells. Furthermore, a subpopulation of CD19-/CD20-/IgM /IgG B-cells contributes to elicited xenoreactive antibody responses.
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