Abstract
Since the first heart transplant, refinement of donor and recipient selection methods, better donor heart management, and advances in immunosuppression have significantly improved survival. In this first of two articles, a perspective of the current realities of cardiac transplantation is shown, as well as the challenges to sustain services worldwide, and some of the new developments, both presently available and just beyond the horizon. Topics that will be covered in this first part include the donor and recipient demographics, as well as recent advances in transplantation immunology, allograft vasculopathy, and immune tolerance.
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